Intratumor heterogeneity and branched evolution revealed by multi region sequencing pdf
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- Tumour evolution: from linear paths to branched trees
- Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
- Overview on Clinical Relevance of Intra-Tumor Heterogeneity
Tumour evolution: from linear paths to branched trees
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Adrenocortical carcinoma is a rare cancer with poor but heterogeneous prognosis. The main prognostic factors used in clinical practice at present are the tumor extension, best reflected by the ENSAT stage 2 , and the tumor proliferation, estimated either by mitotic count 3 or Ki67 proliferation index 4 , 5. However, the prognosis still varies widely among tumors with the same tumor stage and proliferation index 6. Recently, pan-genomic studies have identified molecular subtypes closely associated with prognosis 7 , 8. This subgroup is associated with very poor outcome. This subgroup is associated with a better outcome.
Tumor Heterogeneity View all 7 Articles. Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical oncology. In particular, intra-tumor heterogeneity ITH is closely related to cancer progression, resistance to therapy, and recurrences. It is interconnected with complex molecular mechanisms including spatial and temporal phenomena, which are often peculiar for every single patient. It is important to consider the different types of ITH as a whole for any patient to investigate on cancer progression, prognosis, and treatment opportunities.
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors. Comprehensive genomic analyses of cancers have revealed substantial intrapatient molecular heterogeneities that may explain some instances of drug resistance and treatment failures. Examination of the clonal composition of an individual tumor and its evolution through disease progression and treatment may enable identification of precise therapeutic targets for drug design. Multi-region and single-cell sequencing are powerful tools that can be used to capture intratumor heterogeneity. We collected over tumor samples from patients corresponding to 45 different types of cancer.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Gerlinger and Andrew J. Rowan and S. Horswell and M. Math and J.
Intratumor Heterogeneity and Branched Evolution Revealed. by Multiregion Sequencing. Marco Gerlinger, M.D., Andrew J. Rowan.
Overview on Clinical Relevance of Intra-Tumor Heterogeneity
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Recent advances in next-generation sequencing have opened a new prospect in the field of cancer genomics and cancer evolution. Using next-generation sequencing, researchers have revealed that the occurrence of somatic events such as mutations and copy number alterations is associated with tumor evolution and genomic diversity in tumors, which is known as tumor heterogeneity 1. Tumor heterogeneity includes interpatient tumor heterogeneity 2 , intratumoral heterogeneity 3 , 4 , intermetastatic heterogeneity 5 - 8 , and intrametastatic heterogeneity 9.
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